Current Projects

The Clinical Research Program conducts studies aimed at the prevention of disease and injury by early identification of risk factors, the mitigation of the negative health consequences of disease and injury through comparative effectiveness research and the provision of treatments that quicken recovery and reduce disability. Below is a summary of current clinical research projects being conducted in our department.


Current Clinical Research Projects in the George Washington University Emergency Department

Study Name

Principal Investigator


Brief Project Description


Dr. Andrew Meltzer

Seamus Moran

VACTIV-6 study is a platform protocol designed to evaluate multiple repurposed oral medications for non-hospitalized participants with mild to moderate SARS-CoV-2 infection suitable for a wide range of settings within healthcare systems and in community settings where it can be integrated in subsequent treatment plans. 

Link for more information:


Dr. David Yamane and Dr. Andrew Meltzer

Priscilla Muhanji

This is a randomized control trial to determine effectiveness of high flow nasal canula relative to standard BIPAP for patients with COPD


Dr. Neal Sikka

David Li

A pilot study and needs assessment on the use of Digital Health in households with barriers to technology and a history of hypertension. 

Link for more information:

Ultrasound versus palpation to locate the crichothyroid membrane in the ED: A randomized trial

Dr. Keith Boniface and Dr. Jordan Dow

Nicole Hall

This is a randomized blinded prospective trial comparing the accuracy of palpation to identify the cricothyroid membrane (CTM) compared with ultrasound location of the CTM, using the reference standard of CT to determine accuracy.

Cannabanoid Hyperemesis Syndrome - Pilot Study

Dr. Andrew Meltzer

Nicole Hall

This is a prospective observational study to evaluate current management and symptom resolution of emergency department patients who present with Cannabanoid Hyperemesis Syndrome.

Depression, Anxiety, and Drug Use in ED Patients with Recurrent Abdominal Pain (DAD RAP)

Dr. Andrew Meltzer

Nicole Hall

This is a survey-based study to provide high level evidence to support or refute the question about screening for drug use, depression, and/or anxiety to inform the management of low-risk, recurrent abdominal pain in the ED.

Urgent Care Management of Respiratory Illness Enabled with Novel Testing Pathway (URGENT): A Randomized Controlled Trial of Respiratory PCR versus Standard Care

Dr. Andrew Meltzer

Nicole Hall

This is a randomized controlled trial examining the use of the BioFire PCR Respiratory Panel versus standard care procedures in patients with respiratory illness symptoms who seek care at our Immediate and Primary Care facilities. 

Enhancing U.S. Surveillance of Laboratory Confirmed SARS-CoV-2, Influenza, and other Respiratory Viruses through a Network of Emergency Departments (RECOVER CDC)

Dr. Andrew Meltzer

Meylakh Barshay

Multi-site, ED surveillance study which provides CDC and states with critical information necessary to determine rates of respiratory illness in ED settings and the percent of specimens testing positive for SARS-CoV-2, influenza, or other respiratory viruses in both hospitalized and non-hospitalized ED patients.

Personalized Prenatal Care with Remote Patient Monitoring and Digital Health Interface to Detect Early Signs of Adverse Events in Pregnancy (BABYSCRIPTS) Dr. Andrew Meltzer Nicole Hall

This is phase one of a multi-phase post-market study to evaluate the use of Babyscripts in routine prenatal care. Individual patient- level data analysis on mixed-effects models will be performed for major outcome measures (pre-term birth, gestational diabetes and preeclampsia to determine whether usage of the Babyscripts app affects pregnancy outcomes.